Cell Metric CLD™ success in US biopharma for single cell cloning

Solentim system offers substantial economic benefits

Bournemouth, UK – 8 July 2013: Due to the significant time saving advantages of their Cell Metric™ systems, Solentim, the market-leading developer of innovative tools for shortening steps in the upstream cell line development workflow, have had their best quarter of sales revenues to date. This includes multiple shipments of Cell Metric™ systems to customers in the US and a repeat order from US biopharma. 

Cell Metric CLD™ is a bench-top imaging station, which includes a 10 plate automated plate loader. The system addresses several key stages in the upstream cell line development workflow, including clone screening  and documentation of monoclonality (for regulatory submissions), from  either seeding single cells into 96 well plates with limited dilutions or by FACS sorting. The Cell Metric CLD™ also measures clone stability and growth rates by direct non-invasive cell counting in each well without having to remove a sample. Growth data can then be assessed with protein productivity measurements such as ELISA assay data in the same wells. In this way normalised protein productivity and titre can be calculated to identify and rank the best protein producers. The Cell Metric CLD™ is capable of detecting all cells, even immediately after seeding, affording a significant time advantage.

Automated clone imaging and screening have become a routine element of any new cell line development process. Cell Metric CLD™ has quickly become established as the market-leading clone imager with significantly better optics and automated detection capabilities than previous generation products. Aaron Figg, Managing Director of Solentim commented, "Customers have already reported substantial time savings of up to 3 months for a new cell line using the Cell Metric™ systems where the earlier and higher quality images have negated the need for further rounds of sub-cloning. The economic benefits of this are significant."

For more information please visit the Cell Metric CLD™ product page.

Editors Notes

About Solentim

Commercial cell line development for biopharmaceutical production is a high value process which is intrinsically expensive and takes a significant amount of time. Solentim is dedicated to the development of innovative tools to shorten steps in the upstream cell line development workflow and facilitate cell line scale-up. The Cell MetricTM is a bench-top imaging station for clone screening, clone growth and stability measurements.