Clarity in cell line development

Solentim’s Verified Partners & Collaborations

Early Assessment of Clone Critical Quality Attributes
Valitacell brings together knowledge of bioprocessing with deep learning and predictive analytics to deliver a new level of bioprocess performance.  Valitacell’s novel platform technology, Valita®PIX, along with Solentim’s proprietary instrumentation, will be deployed to create a unique system enabling the automation of data-driven analysis and selection of top clones earlier during the biologic drug manufacturing process..

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Vector Design and High Efficiency GOI Integration
ATUM’s Leap-In transposases and synthetic transposons enable a cost-effective, easily implemented cell line development workflow. The technology delivers high productivity pools and cell lines, resulting in consistent product quality and inherently stable clones.  Coupling ATUM’s Leap-In transposases with Solentim VIPS into CLD workflow, the need to pre-screen or select in-line for high producing clones is eliminated, saving time and money, and enhancing workflow efficiency.

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Supplements to Optimise Clone Outgrowth and Expansion
The ‘Insti’ range of cell culture media supplements are proven to show improved cell growth, colony formation and cloning efficiency. These supplements are suitable for both CHO and HEK cells.  Using the gentle, high efficiency seeding of our VIPS™ single cell cloning system in combination with the InstiGRO™ supplements will ensure a much higher number of wells in the cloning plates successfully produce colonies

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Platform for genome editing

Horizon recently concluded a two-year collaboration with Solentim for the development of an automated manufacturing platform for the genome editing of mammalian cells. The project was funded by Innovate UK. This work also generated data using the VIPS and our proprietary InstiGRO supplements to demonstrate increased outgrowth of HD BIOP3 antibody-expressing cell lines.

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