Clarity in cell line development

Solentim and ATUM to bundle Leap-In Transposase® with the VIPS™ single cell cloning instrument for cell line development

Bournemouth, UK and Newark, CA, USA, 20th April 2020 / Solentim, a global leader in cell line development (CLD) instrumentation, and bioengineering company ATUM, today announced that Solentim will bundle access to the Leap-In Transposase® platform together with the Solentim VIPS™ single cell cloning instrument. Leap-In Transposases enable stable high titer clones to be isolated whilst screening …

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Proof of clonality and its importance in stable cell line development

What is clonality and why is it important Clonality is a crucial step in stable cell line development (CLD) for biotherapeutic workflows and one closely monitored by the medicines’ regulators. Their questions lead to two possible conclusions about how they view the importance of clonality1: Assurance of “clonality” of stable production cell lines is of …

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Continuous innovation of host cell lines for cell line development

Author: Ian Taylor, Chief Commercial Officer, Solentim At last week’s Oxford Global Conference in London, a couple of talks stood out for me on innovations for improving host cell lines in cell line development. First up was Mario Pereira from Horizon Discovery who nicely explained the history of the Company’s HD-BIOP3 GS null knockout for …

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Postcard from BPI Europe in Vienna – Highlights of the Cell Line Development Stream

This annual meeting in early Spring is always a good forum for major new product and technology announcements. In previous years, discussions often mainly centred around assurance of clonality and the requirements of the FDA – still a key consideration for cell line development. Recently, however, the market has expanded from a focus on monoclonal …

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Important considerations for optimising outgrowth from single cells in cloning plates during cell line development

When developing biotherapeutics there are many parts of the process that require optimisation. Cell line development is a key part of this process and there are many aspects where changes can have a dramatic effect on timelines and outcomes. One key area which is challenging to many of our customers is outgrowth of clones in …

Read more Important considerations for optimising outgrowth from single cells in cloning plates during cell line development

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