From static stage to expansion and beyond, ICON is a world’s first.
The ICON with integrated STUDIUS™ data management platform enables scientists in the biotherapeutic development industry to digitally transform their process and make informed decisions quicker, earlier, and more securely.
ICON uniquely combines titer, viability and specific productivity data using low volume assays on a single reader, with the clonality and confluence data from Cell Metric and/or VIPS to track and rank clones automatically, rapidly and consistently from the cloning plate, through fed-batch suspension shaking cultures up to multi-parallel mini bio-reactors such as Ambr®, regardless of the different formats used and without the risk of error.
ICON combines low volume titer and viable cell density assays, enabling measurement of specific productivity for both the static and the shaking suspension cell expansion stages of cell line development. ICON data can be combined with confluency data from Cell Metric and /or VIPS whole well imaging within the STUDIUS data management and analysis platform. This allows automated tracking (with audit trail) and ranking of best performing clones through the various sample formats prior to the scale down bioreactor stage.
ICON Plate-Based Titer
For cloning and expansion stages
- Rapid 96 well plate IgG titer measurements
- Uses just 60 µL sample
- Wide detection range
ICON Automated Viable Cell Counting
For expansion cell stage
- Trypan blue measurements
- Up to 24 samples per run
STUDIUS provides consistency across the CLD workflow from seeding to clone selection and banking via the following attributes
- Secure sample/clone centric tracking and audit trail
- A common data management and analysis platform to ensure raw data integrity
- Common data formats to prevent transcriptional errors and reduce data analysis times from days to minutes, enabling the fastest possible decision making.
STUDIUS tracks the journey of individual clones from seeding to final selection, from 96 well plates through 24 DW blocks and other formats with an audit trail