Clarity in cell line development

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Insightful, valuable, and detailed application notes from Solentim.  Learn how our biopharmaceutical instruments have been used by customers for single cell seeding, clone screening and improved outgrowth and produce stable cell lines.

Single Cell Seeding Conditions for improved colony outgrowth

Optimising colony outgrowth for HD-BIOP3 with the VIPS together with InstiGRO supplements.

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Combining VIPS and ATUM to Accelerate Commercial Cell Line Manufacturing

Development of commercial manufacturing cell lines by screening less than 200 clones using a combination of ATUM's Leap-In transposases with the VIPS and Cell Metric from Solentim.

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Methods for fluorescence qualification of your cloning methods

A thorough review of potential clone screening workflow approaches to cloning method qualification and quality control using the fluorescence Cell Metric application.


Growth rate monitoring in cell line development

The Cell Metric imaging platform enables clone outgrowth to be monitored using confluence after single cell seeding, as well as monitoring colony formation as part of a clone screening and selection process, thereby optimising workflows. Read more here about how the Cell Metric could streamline your cell line development processes.

High throughput hybridoma based antibody discovery

The Cell Metric can greatly improve traditional practices of hybridoma colony identification and monitoring. Our cell imaging system enhances the discovery of new hybridoma clones whose novel sequences can be used as precursors to antibodies in stable cell line development or for diagnostic antibodies. Read more here.

Single cell cloning of FACS-sensitive cells using the VIPS

In this presentation to BPI 2019, Celonic detail significantly improved timelines for CLD using a reduced number of cell plates, which enables delivery of more projects per year with assured clonality.

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Clone imaging and proof of clonality

Using the  Cell Metric® imaging platform, the clonal origin of colonies can be established during cell line development, providing a clear image of the cell and its subsequent growth for documentation. Find out more about how the Cell Metric can help you meet regulatory requirements.

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