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Insightful, valuable, and detailed application notes from Solentim. Learn how our biopharmaceutical instruments have been used by customers for single cell seeding, clone screening and improved outgrowth and produce stable cell lines.
High efficiency single cell cloning of hiPSCs whilst ensuring maintenance of phenotype
Standardizing the process for viable, high efficiency single cell cloning of hiPSCs whilst maintaining stem cell pluripotency.
High efficiency single cell cloning of iPSCs using combination of MatriClone™ and VIPS™
Optimising seeding efficiency and colony outgrowth of iPSCs with the VIPS and a new soluble matrix called MatriClone™.
Improved Outgrowth For HEK 293 Cell Line Development
Gene therapy products - clonality and improved outgrowth for HEK 293 in viral vector production.
Single Cell Seeding Conditions for improved colony outgrowth
Optimising colony outgrowth for HD-BIOP3 with the VIPS together with InstiGRO supplements.
Combining VIPS and ATUM to Accelerate Commercial Cell Line Manufacturing
Development of commercial manufacturing cell lines by screening less than 200 clones using a combination of ATUM's Leap-In transposases with the VIPS and Cell Metric from Solentim.
Methods for fluorescence qualification of your cloning methods
A thorough review of potential clone screening workflow approaches to cloning method qualification and quality control using the fluorescence Cell Metric application.
Growth rate monitoring in cell line development
The Cell Metric imaging platform enables clone outgrowth to be monitored using confluence after single cell seeding, as well as monitoring colony formation as part of a clone screening and selection process, thereby optimising workflows. Read more about how the Cell Metric could streamline your cell line development processes.
High throughput hybridoma based antibody discovery
The Cell Metric can greatly improve traditional practices of hybridoma colony identification and monitoring. Our cell imaging system enhances the discovery of new hybridoma clones whose novel sequences can be used as precursors to antibodies in stable cell line development or for diagnostic antibodies.
Clone imaging and proof of clonality
Using the Cell Metric® imaging platform, the clonal origin of colonies can be established during cell line development, providing a clear image of the cell and its subsequent growth for documentation. Find out more about how the Cell Metric can help you meet regulatory requirements.
Single cell cloning of FACS-sensitive cells using the VIPS
In this presentation to BPI 2019, Celonic detail significantly improved timelines for CLD using a reduced number of cell plates, which enables delivery of more projects per year with assured clonality.
