Scale-up testing

Process map

Following process and media optimization in microplates and shake flasks, around 4-6 clones are taken forward for assessment in bioreactors, after which the final production clone and back-up clone are selected.

At all the scale-up stages and during continual checking of banked production cell lines, clones need to be analysed for viable cell number to track specific protein productivity and volumetric productivity (titre). This can be done with the Cell Metric CLD™.

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